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Blood sugar improvements, blood pressure reductions, and lipid changes tend to reverse once the medication is discontinued
SURMOUNT-5 was a 72-week randomized controlled trial published in the New England Journal of Medicine in May 2025
This translates to approximately 1-2 pounds per week, depending on individual starting weights and compliance with the treatment regimen
Additionally, tirzepatide suppresses glucagon secretion, slows gastric emptying, and reduces appetite through central nervous system pathways
No time separation is needed
Sharma recommends drinking plenty of water throughout the day, especially before meals
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